THE POTENTIAL OF LANGIR (ALBIZIA SAPONARIA LOUR.) STEM BARK AS ANTI-DANDRUFF: IN SILICO AND IN VITRO STUDIES

Objective: Dandruff is a scalp problem that occurs in almost all people the world. The main cause of dandruff growth fungus on scalp. This study aims to evaluate antifungal activity Langir bark against Malassezia furfur, vitro and silico. Methods: In testing was carried out using agar diffusion method with paper disks calculate inhibition zones stem extract fractions, while silico test molecular docking Lanosterol 14-alpha demethylase receptors homology model 5 compounds from genus Albizia as ligands. Results: Antifungal showed significant concentrations (5-20%), also for fractions (p<0.05). However, water fraction had better than others, an zone 17.33 mm at concentration 15% 18.67 20%, positive control (ketoconazole 1%) 16.67 mm. Furthermore, revealed metabolites plant provide binding energy ketoconazole (-10.1 kcal/mol), namely, Tamarixetin 3-rutinoside (-10.7 Quercetin 3-rhamnosyl-galactoside (-10.4 Albiziasaponin A (-11.6 C (-11.9 kcal/mol) D kcal/mol). Conclusion: has inhibiting M. furfur so it can be developed therapeutic alternative anti-dandruff.